Perricone MD Cold Plasma

  • Editors’ Rating: 7.9

  • Detailed Ratings

    Fast Results

  • Tightens and Firms

  • Hydrates/Moisturizes

  • Clinical Study Results

  • Long-Term Results


Cold Plasma is a product by Dr. Perricone that claims to address the 10 visible signs of aging including “wrinkles, enlarged pores, dryness, redness, discoloration, uneven skin tone, impurities, loss of firmness, loss of smoothness, and loss of radiance.” in what they label as a single solution. They further suggest that the cream repairs and nourishes the skin, lifts and firms the skin with DMAE, and corrects the visible signs of aging.

The cream comes in a 1 oz. jar and they recommend twice daily application; once in the morning and again at night, followed by a moisturizer (wait, what happened to the single solution?).

One of the primary active ingredients is Acetyl Hexapeptide-8, and research has shown that this peptide has significant anti-wrinkle efficacy when compared against a placebo group (Source:


Their website reports the following consumer study results:

  • 99% felt that their skin was soft and smooth
  • 94% felt it provided for their skincare needs
  • 92% reported that their skin looked radiant and healthy
  • 91% felt that their skin was infused with moisture

*Time for a little quick education here! It’s important to understand the difference between a consumer study and an independent clinical study. Consumer studies focus on the opinion and feelings of the study participant where an actual clinical study involves measuring and quantifying the actual results.


Dr. Perricone’s Cold Plasma generally has good feedback in online reviews with many users reporting positive results.

My Experience/Opinion:

My overall assessment is positive. I like the texture of the cream and do believe it creates a firming effect. I’m not a fan of the smell however and am somewhat disappointed by the “one solution” claim followed by the suggestion that it should be used with a moisturizer and several other products. Don’t get me wrong, results are important but affordability and value are also things I take into consideration.


The product absorbs well, softens the skin, and does seem to create a noticeable firming effect. The company suggests using it in combination with a moisturizer and eye cream and I would agree with that advice as this is more of a treatment.


  • Suitable for all skin types
  • Good for smoothing and softening
  • No parabens or sulfates
  • Formulated with Acetyl Hexapeptide-8 (Studies have shown benefits)
  • No synthetic dyes


  • The product is expensive at $155 for a 1 oz jar, especially considering that they recommend using it with a separate, $98 cold plasma eye cream and $69 Photo Plasma Anti-Aging Moisturizer.
  • Numerous consumer complaints about a bad “fishy” smell

Price: 1 oz. $155

As with all skin care products individual results may vary and are not guaranteed.


Aqua (Water), Glycerin, Tetrahexyldecyl Ascorbate, Phosphatidylcholine, Isopropyl Palmitate, L-Tyrosine, Butylene Glycol, Glyceryl Stearate, PEG-100 Stearate, Cetearyl Alcohol, Oligopeptide-17, Ceteareth-20, Magnesium Aspartate, Zinc Gluconate, Dimethyl MEA (DMAE), Docosahexaenoic Acid, Ascorbyl Palmitate, Phenoxyethanol, Dimethicone, Caprylyl Glycol, Glycolic Acid, Retinyl Palmitate, Saccaromyces Ferment, Elaeis Guineensis (Palm) Oil, Carbomer, Disodium EDTA, Tocotrienols, Copper Gluconate, Polysorbate 20, Sorbic Acid, Tocopherol, Sodium Hyaluronate, Acetyl Hexapeptide-8, Palmitoyl Oligopeptide, Astaxanthin, Palmitoyl Tetrapeptide-3

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